Ethanolamine → HCID 86707781, compound

HRID 2410137Notes

Reaction equation

HRID 2410137 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([B:10]([OH:12])[OH:11])=[C:6]([O:13][CH3:14])[CH:5]=1)([OH:3])=O.[CH2:15]([CH2:17][NH2:18])[OH:16]>>[OH:16][CH2:15][CH2:17][NH:18][C:1]([C:4]1[CH:9]=[CH:8][C:7]([B:10]([OH:12])[OH:11])=[C:6]([O:13][CH3:14])[CH:5]=1)=[O:3]

Participants

3

Reactant 2

HCID 700EthanolamineHCID 231342764-Borono-3-methoxybenzoic acid

Product 1

HCID 86707781HCID 86707781, compound

Procedure

The title compound was prepared in analogy to the procedure described for Intermediate K from 4-carboxy-2-methoxyphenyl boronic acid and ethanolamine. The solvent was removed and then water and EtOAc were added. The phases were separated and the aqueous one was extracted twice with EtOAc. The organics extracts were combined and dried (Na2SO4), and concentrated. The residue was triturated in acetonitrile to give the title compound. tR: 0.42 min (LC-MS 2); ESI-MS: 240.1 [M+H]+ (LC-MS 2).

Workup

  1. customThe title compound was prepared in analogy to the procedure
  2. customThe solvent was removed
  3. additionwater and EtOAc were added
  4. customThe phases were separated
  5. extractionthe aqueous one was extracted twice with EtOAc
  6. dry with materialdried (Na2SO4)
  7. concentrationconcentrated
  8. customThe residue was triturated in acetonitrile

Sources & evidence

ORD record
ord-fe38c3c817f04c1e98407f973538d2a7
Source dataset
uspto-grants-2014_08
Patent number
US08815926B2

Reaction notes

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