2,6-Dimethyl-4-aminopyrimidine → HCID 86707788, compound

HRID 2410145Notes

Reaction equation

HRID 2410145 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([Br:23])[N:9]([CH:20]([CH3:22])[CH3:21])[C:10]=1[CH:11]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1)O)=[O:5])[CH3:2].[NH2:24][C:25]1[CH:30]=[C:29]([CH3:31])[N:28]=[C:27]([CH3:32])[N:26]=1>>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([Br:23])[N:9]([CH:20]([CH3:22])[CH3:21])[C:10]=1[CH:11]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1)[NH:24][C:25]1[CH:30]=[C:29]([CH3:31])[N:28]=[C:27]([CH3:32])[N:26]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 680392,6-Dimethyl-4-aminopyrimidineHCID 86707749ethyl 2-bromo-5-((4-chlorophenyl)(hydroxy)methyl)-1-isopropyl-1H-imidazole-4-carboxylate

Product 1

HCID 86707788HCID 86707788, compound

Procedure

The title compound was prepared in analogy to the procedure described for step E2 but using intermediate B and 4-amino-2,6-dimethylpyrimidine. After completion, the reaction mixture was extracted with 1M HCl and washed with a saturated NaHCO3 solution. The organic was dried (Na2SO4), filtered and concentrated. The product was used without further purification. tR: 0.82 min (LC-MS 2); ESI-MS: 506.0/508.1 [M+H]+ (LC-MS 2).

Workup

  1. extractionAfter completion, the reaction mixture was extracted with 1M HCl
  2. washwashed with a saturated NaHCO3 solution
  3. dry with materialThe organic was dried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThe product was used without further purification

Sources & evidence

ORD record
ord-362cb062e08647549b9864bae4930f49
Source dataset
uspto-grants-2014_08
Patent number
US08815926B2

Reaction notes

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