Ethyl Acetoacetate → HCID 66747026, compound

HRID 2410176Notes

Reaction equation

[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH:11]2[CH2:16][CH2:15][N:14]([C:17](=[O:21])[CH:18]([CH3:20])[CH3:19])[CH2:13][CH2:12]2)[C:3]=1[C:4]#[N:5].[C:22]([O:28][CH2:29][CH3:30])(=[O:27])[CH2:23][C:24]([CH3:26])=O>>[NH2:5][C:4]1[C:3]2[C:2](=[CH:9][CH:8]=[CH:7][C:6]=2[O:10][CH:11]2[CH2:16][CH2:15][N:14]([C:17](=[O:21])[CH:18]([CH3:19])[CH3:20])[CH2:13][CH2:12]2)[N:1]=[C:24]([CH3:26])[C:23]=1[C:22]([O:28][CH2:29][CH3:30])=[O:27]

Participants

Reactant 2

HCID 8868Ethyl Acetoacetate

HCID 66746952HCID 66746952, compound

Product 1

HCID 66747026HCID 66747026, compound

Procedure

Prepared as in Example Ba from 2-amino-6-((1-isobutyrylpiperidin-4-yl)oxy)benzonitrile (Example 10b) and ethyl acetoacetate as an off-white solid (82%). MS 400 (MH+).

Sources & evidence

ORD record: ord-fd6949d3ce1c4ee5ac2d264df6935275
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08815956B2

Reaction notes

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