HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Remitch
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (E)-N-(17-(Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan-6beta-yl)-3-(furan-3-yl)-N-methylprop-2-enamide | HCID 6445230 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Remitch | HCID 6918287 | — |
Reaction Steps
First, 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan was dispersed in methanol solvent, and an hydrogen chloride organic solution was added thereto to form a second solution. Then, after stirring for 15 minutes, the second solution was concentrated and dried to obtain a crystal of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan hydrochloride. The amount of each component in Examples 1-6 is shown in Table 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816084B1 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-1b968eaa66ab40c0b4f558b25236a631 |
| Source note | uspto-grants-2014_08 |