Hydrochloric Acid → Remitch

HRID 2410253Notes

Reaction equation

HRID 2410253 reaction equation
[CH:1]1([CH2:4][N:5]2[CH2:23][CH2:22][C@:12]34[C:13]5[C:14]6[O:21][C@H:11]3[C@H:10]([N:24]([CH3:34])[C:25](=[O:33])/[CH:26]=[CH:27]/[C:28]3[CH:32]=[CH:31][O:30][CH:29]=3)[CH2:9][CH2:8][C@@:7]4([OH:35])[C@H:6]2[CH2:19][C:18]=5[CH:17]=[CH:16][C:15]=6[OH:20])[CH2:3][CH2:2]1.[ClH:36]>CO>[ClH:36].[CH:1]1([CH2:4][N:5]2[CH2:23][CH2:22][C@:12]34[C:13]5[C:14]6[O:21][C@H:11]3[C@H:10]([N:24]([CH3:34])[C:25](=[O:33])/[CH:26]=[CH:27]/[C:28]3[CH:32]=[CH:31][O:30][CH:29]=3)[CH2:9][CH2:8][C@@:7]4([OH:35])[C@H:6]2[CH2:19][C:18]=5[CH:17]=[CH:16][C:15]=6[OH:20])[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 6445230(E)-N-(17-(Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan-6beta-yl)-3-(furan-3-yl)-N-methylprop-2-enamide

Product 1

HCID 6918287Remitch

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

First, 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan was dispersed in methanol solvent, and an hydrogen chloride organic solution was added thereto to form a second solution. Then, after stirring for 15 minutes, the second solution was concentrated and dried to obtain a crystal of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan hydrochloride. The amount of each component in Examples 1-6 is shown in Table 1.

Workup

  1. customto form a second solution
  2. concentrationthe second solution was concentrated
  3. customdried

Sources & evidence

ORD record
ord-1b968eaa66ab40c0b4f558b25236a631
Source dataset
uspto-grants-2014_08
Patent number
US08816084B1

Reaction notes

Loading…