HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 2-Methylpropyl 5-bromo-4-fluoro-2-methyl-1H-benzimidazole-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Isobutyl chloroformate | HCID 62365 | — |
| Reactant | 4-Bromo-3-fluorobenzene-1,2-diamine | HCID 2783203 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Methylpropyl 5-bromo-4-fluoro-2-methyl-1H-benzimidazole-1-carboxylate | HCID 68777136 | — |
Reaction Steps
Synthesized according to the method of reagent preparation 19 using 5 4-bromo-3-fluorobenzene-1,2-diamine and acetylation with acetic anhydride in tetrahydrofurane in step 1 then treatment with isobutyl chloroformate in step 3. MS (EI) for C13H14BrN2O2: 328, 330 (MH+, Br isotope pattern).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08648066B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-021d83c5fbf44ad4bd64e1e375e77f4e |
| Source note | uspto-grants-2014_02 |