Methyl 2,2-dimethyl-3-oxopropanoate → HCID 69319055, compound

HRID 2410339Notes

Reaction equation

HRID 2410339 reaction equation
[CH2:1]([O:5][C:6]1[C:11]2[C:12]([O:15][CH2:16][CH:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)=[N:13][O:14][C:10]=2[CH:9]=[CH:8][CH:7]=1)[CH:2]([CH3:4])[CH3:3].[CH3:23][C:24]([CH3:31])([CH:29]=O)[C:25]([O:27][CH3:28])=[O:26].C(C1(C(OC)=O)CCC1)=O>>[CH2:1]([O:5][C:6]1[C:11]2[C:12]([O:15][CH2:16][CH:17]3[CH2:22][CH2:21][N:20]([CH2:23][C:24]([CH3:31])([CH3:29])[C:25]([O:27][CH3:28])=[O:26])[CH2:19][CH2:18]3)=[N:13][O:14][C:10]=2[CH:9]=[CH:8][CH:7]=1)[CH:2]([CH3:4])[CH3:3]

Participants

4

Reactant 3

HCID 11137194Methyl 2,2-dimethyl-3-oxopropanoateHCID 15656335Methyl 1-formylcyclobutane-1-carboxylateHCID 693169774-Isobutoxy-3-(piperidin-4-ylmethoxy)-1,2-benzisoxazole

Product 1

HCID 69319055HCID 69319055, compound

Procedure

The title compound was prepared according to the procedure described in Step 3 of EXAMPLE 2 using 4-isobutoxy-3-(piperidin-4-ylmethoxy)-1,2-benzisoxazole (EXAMPLE 10, Step 1) and methyl 2,2-dimethyl-3-oxopropanoate (0.96 mg, 0.74 mmol, Tetrahedron Asymmetry 2003, 14, 3371-3378) instead of 3-(piperidin-4-ylmethoxy)-4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazole and methyl 1-formylcyclobutanecarboxylate.

Sources & evidence

ORD record
ord-c8fe35b51dc44c169d9c8147793e397e
Source dataset
uspto-grants-2014_08
Patent number
US08816090B2

Reaction notes

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