Ethanolamine → 5-bromo-N-(2-hydroxyethyl)-2-(methylamino)pyridine-3-sulfonamide

HRID 241043Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([S:10](Cl)(=[O:12])=[O:11])[C:5]([NH:8][CH3:9])=[N:6][CH:7]=1.BrC1C=CC(NC)=NC=1.[NH2:23][CH2:24][CH2:25][OH:26]>>[Br:1][C:2]1[CH:3]=[C:4]([S:10]([NH:23][CH2:24][CH2:25][OH:26])(=[O:12])=[O:11])[C:5]([NH:8][CH3:9])=[N:6][CH:7]=1

Participants

Reactant 3

HCID 700Ethanolamine

HCID 156456635-Bromo-N-methylpyridin-2-amine

HCID 866478215-Bromo-2-(methylamino)pyridine-3-sulfonyl chloride

Product 1

HCID 668205615-bromo-N-(2-hydroxyethyl)-2-(methylamino)pyridine-3-sulfonamide

Procedure

Prepared according to the methods described in reagent preparation 25 using 5-bromo-2-(methylamino)pyridine-3-sulfonyl chloride (prepared from 5-bromo-N-methylpyridin-2-amine using analogous conditions to those described in WO2008144463) and 2-aminoethanol in step 1.

Workup

customPrepared

Sources & evidence

ORD record: ord-10afbe0e984e40d791253d8fe910203b
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08648066B2

Reaction notes

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