Sarcosine t-butyl ester hydrochloride → Glycine, N-[(3-cyano-4,5-difluorophenyl)methyl]-N-methyl-, 1,1-dimethylethyl ester

HRID 2410549Notes

Reaction equation

HRID 2410549 reaction equation
Br[CH2:2][C:3]1[CH:4]=[C:5]([F:12])[C:6]([F:11])=[C:7]([CH:10]=1)[C:8]#[N:9].Cl.[CH3:14][NH:15][CH2:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18]>>[C:8]([C:7]1[CH:10]=[C:3]([CH:4]=[C:5]([F:12])[C:6]=1[F:11])[CH2:2][N:15]([CH3:14])[CH2:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])#[N:9]

Participants

3

Reactant 2

HCID 11252350Sarcosine t-butyl ester hydrochlorideHCID 66678615HCID 66678615, compound

Product 1

HCID 66678215Glycine, N-[(3-cyano-4,5-difluorophenyl)methyl]-N-methyl-, 1,1-dimethylethyl ester

Procedure

The title compound was prepared following general procedure 10, starting from 5-(bromomethyl)-2,3-difluorobenzonitrile and tert-butyl N-methylglycinate hydrochloride. It was obtained as a yellow oil (618 mg, 88%). HPLC (Method A) Rt 2.75 (Purity: 97%).

Sources & evidence

ORD record
ord-05208342b3884f14b2189e5ada7891e8
Source dataset
uspto-grants-2014_08
Patent number
US08815919B2

Reaction notes

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