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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2410549Generated: October 30, 2026

Sarcosine t-butyl ester hydrochloride → Glycine, N-[(3-cyano-4,5-difluorophenyl)methyl]-N-methyl-, 1,1-dimethylethyl ester

https://huagongshe.com/reaction/2410549

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSarcosine t-butyl ester hydrochlorideHCID 11252350—
ReactantHCID 66678615HCID 66678615—
ProductGlycine, N-[(3-cyano-4,5-difluorophenyl)methyl]-N-methyl-, 1,1-dimethylethyl esterHCID 66678215—

Reaction Steps

The title compound was prepared following general procedure 10, starting from 5-(bromomethyl)-2,3-difluorobenzonitrile and tert-butyl N-methylglycinate hydrochloride. It was obtained as a yellow oil (618 mg, 88%). HPLC (Method A) Rt 2.75 (Purity: 97%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08815919B2
Source datasetuspto-grants-2014_08
ORD IDord-05208342b3884f14b2189e5ada7891e8
Source noteuspto-grants-2014_08