2-(Methoxymethyl)-2'-methylbiphenyl-4-carboxylic acid → (3-{5-[2-(Methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)methanol

HRID 2410587Notes

Reaction equation

HRID 2410587 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[C:8]([C:10]([OH:12])=O)[CH:7]=[CH:6][C:5]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH3:19].O[N:21]=[C:22]([NH2:31])[C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH2:29][OH:30])[CH:24]=1>>[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[C:8]([C:10]2[O:12][N:31]=[C:22]([C:23]3[CH:24]=[C:25]([CH2:29][OH:30])[CH:26]=[CH:27][CH:28]=3)[N:21]=2)[CH:7]=[CH:6][C:5]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH3:19]

Participants

3

Reactant 2

HCID 594958222-(Methoxymethyl)-2'-methylbiphenyl-4-carboxylic acidHCID 74865044N'-hydroxy-3-(hydroxymethyl)benzimidamide

Product 1

HCID 59495704(3-{5-[2-(Methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)methanol

Procedure

The title compound was prepared following the general procedure 3 starting from Intermediate 3 and Intermediate 70 and was isolated as a yellow oil. HPLC (Method A) Rt 5.16 min (Purity: 97.0%).

Workup

  1. customwas isolated as a yellow oil

Sources & evidence

ORD record
ord-2a733703ea6b4180b55427e33933af88
Source dataset
uspto-grants-2014_08
Patent number
US08815919B2

Reaction notes

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