反应详情

温度

0 °C

To a solution of 2-(3-{5-[2-(methoxymethyl)-2′-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)ethanol (0.2 mmol) in DCM (2 mL) at 0° C. was added DIEA (71 μL, 0.4 mmol) and mesyl chloride (17 μL, 0.22 mmol). The resulting mixture was stirred at 0° C. for 10 minutes, allowed to warm to RT and stirred for 2 hours. The mixture was diluted with DCM (20 mL) and washed with a saturated aqueous solution of NaHCO3. The aqueous layer was extracted with DCM (3×20 mL). The combined organic fractions were dried (MgSO4), filtered and the solvent removed in vacuo. The crude residue was all used in the next step without further purification.

1. temperatureto warm to RT
2. stirringstirred for 2 hours
3. washwashed with a saturated aqueous solution of NaHCO3
4. extractionThe aqueous layer was extracted with DCM (3×20 mL)
5. dry with materialThe combined organic fractions were dried (MgSO4)
6. filtrationfiltered
7. customthe solvent removed in vacuo
8. customall used in the next step without further purification