反应详情

温度

130 °C

To a solution of 2-(3-{5-[2-(methoxymethyl)-2′-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenethyl methanesulfonate (0.2 mmol) in dioxane (2 mL) was added potassium carbonate (165 mg, 1.2 mmol) and tert-butyl N-methylglycinate, hydrochloride salt (0.60 mmol). The mixture was heated at 130° C. for 72 hours, diluted with DCM (5 mL) and water (5 mL). The aqueous layer was extracted with DCM (3×20 mL), the combined organic fractions were dried (MgSO4), filtered and the solvent removed in vacuo. The residue was purified by flash chromatography (silica, Pet Ether/EtOAc) to give the title compound as a colorless oil (86 mg, 72%).

1. extractionThe aqueous layer was extracted with DCM (3×20 mL)
2. dry with materialthe combined organic fractions were dried (MgSO4)
3. filtrationfiltered
4. customthe solvent removed in vacuo
5. customThe residue was purified by flash chromatography (silica, Pet Ether/EtOAc)