1-Methyl-4-piperidone → HCID 66605455, compound

HRID 2410824Notes

Reaction equation

HRID 2410824 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[N:14]=[C:13]([C:15]4[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=4)[CH:12]=[C:11]([C:25]([NH2:27])=[O:26])[C:7]=3[NH:8][C:9]=2[CH:10]=1.[CH3:28][N:29]1[CH2:34][CH2:33][C:32](=O)[CH2:31][CH2:30]1>CO>[CH3:28][N:29]1[CH2:34][CH2:33][CH:32]([NH:1][C:2]2[CH:3]=[CH:4][C:5]3[C:6]4[N:14]=[C:13]([C:15]5[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=5)[CH:12]=[C:11]([C:25]([NH2:27])=[O:26])[C:7]=4[NH:8][C:9]=3[CH:10]=2)[CH2:31][CH2:30]1

Participants

4

Reactant 2

HCID 740491-Methyl-4-piperidoneHCID 66604922HCID 66604922, compound

Product 1

HCID 66605455HCID 66605455, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

This was similarly prepared 7-amino-2-(3-(trifluoromethyl)phenyl)-5H-pyrido[3,2-b]indole-4-carboxamide and 1-methylpiperidin-4-one. MS (ESI) m/z 468.30 (M+H); HPLC retention time of 1.85 min with Xbridge S10 4.6×50 mm column, 3 min gradient, 0-100% B, 4 mL/min. Solvent A: 95% MeOH—5% H2O—0.1% TFA; Solvent B: 5% MeOH—95% H2O—0.1% TFA.

Workup

  1. custom4.6×50 mm column, 3 min gradient, 0-100% B, 4 mL/min

Sources & evidence

ORD record
ord-12d1fe8d14294d5aafb2a0f8804c23ff
Source dataset
uspto-grants-2014_08
Patent number
US08815840B2

Reaction notes

Loading…