反应详情

温度

185 °C

(1H-Indol-6-yl)(morpholino)methanone (200 mg, 0.869 mmol), ethyl 5-phenyl-1,2,4-triazine-3-carboxylate (299 mg, 1.303 mmol) and 1-methoxy-2-(2-methoxyethoxy)ethane (556 μL, 3.91 mmol) were mixed in a sealed microwave vial. The mixture was heated in microwave at 185° C. for 8 hrs. The mixture was purified using preparative HPLC to give titled product. MS (ESI) m/z 430.09 (M+H)+. 1H NMR (DMSO-d6) δ ppm 11.82 (s, 1H), 9.13 (s, 1H), 8.47 (d, 1H, J=7.9), 8.27 (d, 2H, J=7.7), 7.81 (s, 1H), 7.56(t, 2H, J=7.6), 7.44 (t, 1H, J=7.3), 7.36 (d, 1H, J=7.9), 4.57 (q, 2H, J=7.1), 3.67-3.45 (bm, 8H), 1.47 (t, 3H, J=7.1). NOE and ghmbc were used to confirm the structure.

1. customThe mixture was purified