反应详情

温度

80 °C

7-Amino-3-bromo-9H-carbazole-1-carboxamide 470B (400 mg, 1.315 mmol), N-benzyl-2-chloro-N-(2-chloroethyl)ethanamine hydrochloride (707 mg, 2.63 mmol) and sodium carbonate (697 mg, 6.58 mmol) were mixed in DMF (8 mL) in a sealed microwave vial. The vial was degassed and filled with N2. The mixture was heated at 80° C. for 16 hrs in an oil bath. The mixture was then heated in microwave at 200 C for 1 hr. The mixture was purified using preparative HPLC to give titled product. MS (ESI) m/z 463.07 (M+H)+.

1. customThe vial was degassed
2. additionfilled with N2
3. temperatureThe mixture was then heated in microwave at 200 C for 1 hr
4. customThe mixture was purified