HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2410921Generated: October 30, 2026
Sodium Carbonate → 3-bromo-7-(6-morpholinopyridin-3-yl)-9H-carbazole-1-carboxamide
https://huagongshe.com/reaction/2410921
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl)morpholine | HCID 2795363 | — |
| Reactant | 3-bromo-7-iodo-9H-carbazole-1-carboxamide | HCID 66604592 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 3-bromo-7-(6-morpholinopyridin-3-yl)-9H-carbazole-1-carboxamide | HCID 66604364 | — |
Reaction Steps
3-Bromo-7-iodo-9H-carbazole-1-carboxamide 481A (100 mg, 0.241 mmol), 4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)morpholine (84 mg, 0.289 mmol), PdCl2(dppf)-CH2Cl2 adduct (39.4 mg, 0.048 mmol), and Na2CO3 (2M) (0.602 mL, 1.205 mmol) were mixed with DME (4 mL) in a sealed microwave vial. The mixture was flushed with N2 and heated at 105° C. in an oil bath for 5 hrs. The mixture was used as it is. MS (ESI) m/z 450.97 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08815840B2 |
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| Source dataset | uspto-grants-2014_08 |
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| ORD ID | ord-e0334d5668754c9e9056aa97f1d115dd |
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| Source note | uspto-grants-2014_08 |
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