Methanesulfonyl chloride → (S)-3-isopropylisothiazolidine 1,1-dioxide

HRID 2411129Notes

Reaction equation

[NH2:1][C@H:2]([CH:5]([CH3:7])[CH3:6])[CH2:3]O.[CH3:8][S:9](Cl)(=[O:11])=[O:10]>>[CH:5]([C@@H:2]1[CH2:3][CH2:8][S:9](=[O:11])(=[O:10])[NH:1]1)([CH3:7])[CH3:6]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 6950587D-Valinol

Product 1

HCID 86676751(S)-3-isopropylisothiazolidine 1,1-dioxide

Procedure

Using (R)-2-amino-3-methyl-1-butanol (5.0 g) and methanesulfonyl chloride (7.7 mL) and by the reaction and treatment in the same manner as in Preparation Example 1, the title compound (3.48 g) was obtained.

Workup

customby the reaction and treatment in the same manner
customas in Preparation Example 1

Sources & evidence

ORD record: ord-c546fe0dee5b4417bbcf5106f81db01e
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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