3-Chloropropanesulphonyl chloride → 4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-methoxybenzoic acid

HRID 2411141Notes

Reaction equation

HRID 2411141 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[C:4]([O:12][CH3:13])[CH:3]=1.Cl[CH2:15][CH2:16][CH2:17][S:18](Cl)(=[O:20])=[O:19]>>[O:19]=[S:18]1(=[O:20])[CH2:17][CH2:16][CH2:15][N:1]1[C:2]1[CH:11]=[CH:10][C:5]([C:6]([OH:8])=[O:7])=[C:4]([O:12][CH3:13])[CH:3]=1

Participants

3

Reactant 2

HCID 154103-Chloropropanesulphonyl chlorideHCID 168705Methyl 4-amino-o-anisate

Product 1

HCID 712520824-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-methoxybenzoic acid

Procedure

Using methyl 4-amino-2-methoxybenzoate (1.01 g) and 3-chloropropane-1-sulfonyl chloride (0.9 mL) and by the reaction and treatment in the same manner as in Preparation Example 16, the title compound (839 mg) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 16

Sources & evidence

ORD record
ord-4fdd1796336a42e6b75122283533e884
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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