3-Chloropropanesulphonyl chloride → 4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-fluorobenzoic acid

HRID 2411147Notes

Reaction equation

HRID 2411147 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[C:4]([F:12])[CH:3]=1.Cl[CH2:14][CH2:15][CH2:16][S:17](Cl)(=[O:19])=[O:18]>>[O:18]=[S:17]1(=[O:19])[CH2:16][CH2:15][CH2:14][N:1]1[C:2]1[CH:11]=[CH:10][C:5]([C:6]([OH:8])=[O:7])=[C:4]([F:12])[CH:3]=1

Participants

3

Reactant 2

HCID 154103-Chloropropanesulphonyl chlorideHCID 21957875Methyl 4-amino-2-fluorobenzoate

Product 1

HCID 712528614-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-fluorobenzoic acid

Procedure

Using methyl 4-amino-2-fluorobenzoate (1.02 g) and 3-chloropropane-1-sulfonyl chloride (0.97 mL) and by the reaction and treatment in the same manner as in Preparation Example 16, the title compound (1.09 g) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 16

Sources & evidence

ORD record
ord-873014ac9eff437f97dc5758132085ad
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…