3-Chloropropanesulphonyl chloride → Ethyl 6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)nicotinate

HRID 2411149Notes

Reaction equation

HRID 2411149 reaction equation
[NH2:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][N:3]=1.Cl[CH2:14][CH2:15][CH2:16][S:17](Cl)(=[O:19])=[O:18]>>[O:18]=[S:17]1(=[O:19])[CH2:16][CH2:15][CH2:14][N:1]1[C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 154103-Chloropropanesulphonyl chlorideHCID 235927Ethyl 6-Aminonicotinate

Product 1

HCID 71251937Ethyl 6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)nicotinate

Procedure

Using ethyl 6-aminonicotinate (2.02 g) and 3-chloropropane-1-sulfonyl chloride (1.8 mL) and by the reaction and treatment in the same manner as in Preparation Example 17, the title compound (2.29 g) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 17

Sources & evidence

ORD record
ord-053c09d130f14d83a6605e3e02a66ae6
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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