3-Chloropropanesulphonyl chloride → 2,4-Bis(1,1-dioxo-1lambda6-isothiazolidin-2-yl)benzoic acid

HRID 2411160Notes

Reaction equation

HRID 2411160 reaction equation
[NH2:1][C:2]1[CH:12]=[C:11]([NH2:13])[CH:10]=[CH:9][C:3]=1[C:4]([O:6]CC)=[O:5].Cl[CH2:15][CH2:16][CH2:17][S:18](Cl)(=[O:20])=[O:19]>>[O:19]=[S:18]1(=[O:20])[CH2:17][CH2:16][CH2:15][N:1]1[C:2]1[CH:12]=[C:11]([N:13]2[CH2:15][CH2:16][CH2:17][S:18]2(=[O:20])=[O:19])[CH:10]=[CH:9][C:3]=1[C:4]([OH:6])=[O:5]

Participants

3

Reactant 2

HCID 154103-Chloropropanesulphonyl chlorideHCID 22096618Ethyl 2,4-diaminobenzoate

Product 1

HCID 712522932,4-Bis(1,1-dioxo-1lambda6-isothiazolidin-2-yl)benzoic acid

Procedure

Using ethyl 2,4-diaminobenzoate (2.21 g) and 3-chloropropane-1-sulfonyl chloride (4 mL) and by the reaction and treatment in the same manner as in Preparation Example 16, the title compound (1.33 g) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 16

Sources & evidence

ORD record
ord-306ad5a852224c4b87d88f5c735fa1a6
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…