3-Chloropropanesulphonyl chloride → Methyl 4-[1-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-1-methylethyl]benzoate

HRID 2411166Notes

Reaction equation

HRID 2411166 reaction equation
[NH2:1][C:2]([C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1)([CH3:4])[CH3:3].Cl[CH2:16][CH2:17][CH2:18][S:19](Cl)(=[O:21])=[O:20]>>[O:20]=[S:19]1(=[O:21])[CH2:18][CH2:17][CH2:16][N:1]1[C:2]([C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1)([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 154103-Chloropropanesulphonyl chlorideHCID 57572309Methyl 4-(1-amino-1-methylethyl)benzoate

Product 1

HCID 71252862Methyl 4-[1-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-1-methylethyl]benzoate

Procedure

Using methyl 4-(1-amino-1-methylethyl)benzoate (570 mg) and 3-chloropropane-1-sulfonyl chloride (0.47 mL) and by the reaction and treatment in the same manner as in Preparation Example 17, the title compound (862 mg) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 17

Sources & evidence

ORD record
ord-56068c774a014b379e91b2179bd9beef
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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