1,3-Propanesultam → HCID 71252272, compound

HRID 2411170Notes

Reaction equation

HRID 2411170 reaction equation
Br[CH2:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][N:4]=1.[O:13]=[S:14]1(=[O:19])[CH2:18][CH2:17][CH2:16][NH:15]1>>[O:13]=[S:14]1(=[O:19])[CH2:18][CH2:17][CH2:16][N:15]1[CH2:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][N:4]=1

Participants

3

Reactant 2

HCID 6421571,3-PropanesultamHCID 127522376-Bromomethyl-nicotinic acid methyl ester

Product 1

HCID 71252272HCID 71252272, compoundYield 73%

Procedure

Using methyl 6-bromomethylnicotinate (500 mg) and 1,1-dioxo-1λ6-isothiazolidine (290 mg) and by the reaction and treatment in the same manner as in Preparation Example 42, the title compound (429 mg) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 42

Sources & evidence

ORD record
ord-97a518bed642420eb6262dca1bfbd2f0
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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