反应详情

3-Benzoyl-1-(4-methoxybenzyl)-4-methylimidazolidin-2-one (220 mg) described in Preparation Example 55 was dissolved in trifluoroacetic acid (2 mL), and the mixture was stirred for 4 hr under heated reflux. The solvent was evaporated from the reaction mixture, 5% aqueous sodium hydrogen carbonate solution was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with 5% aqueous sodium hydrogen carbonate solution and saturated brine, and the solvent was evaporated. The obtained residue was purified by column chromatography (hexane:ethyl acetate) to give the title compound (135 mg).

1. temperatureunder heated
2. temperaturereflux
3. customThe solvent was evaporated from the reaction mixture, 5% aqueous sodium hydrogen carbonate solution
4. additionwas added
5. extractionthe mixture was extracted with ethyl acetate
6. washThe organic layer was washed with 5% aqueous sodium hydrogen carbonate solution and saturated brine
7. customthe solvent was evaporated
8. customThe obtained residue was purified by column chromatography (hexane:ethyl acetate)