Methanesulfonyl chloride → methyl (S)-4-(1-methanesulfonylaminoethyl)benzoate

HRID 2411193Notes

Reaction equation

HRID 2411193 reaction equation
[NH2:1][C@H:2]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)[CH3:3].[CH3:14][S:15](Cl)(=[O:17])=[O:16]>>[CH3:14][S:15]([NH:1][C@H:2]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)[CH3:3])(=[O:17])=[O:16]

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 17751895Methyl 4-((1S)-1-aminoethyl)benzoate

Product 1

HCID 71262918methyl (S)-4-(1-methanesulfonylaminoethyl)benzoate

Procedure

Using methyl (S)-4-(1-aminoethyl)benzoate (0.61 g) and methanesulfonyl chloride (0.29 mL) and by the reaction and treatment in the same manner as in Preparation Example 71, the title compound (0.81 g) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 71

Sources & evidence

ORD record
ord-fb924fb53f7e423d92e701fbc088fc69
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…