2,3-Dichloro-5-(trifluoromethyl)pyridine → 1-(3-Methyl-5-trifluoromethylpyridin-2-yl)piperazine

HRID 2411212Notes

Reaction equation

HRID 2411212 reaction equation
Cl[C:2]1[C:7](Cl)=[CH:6][C:5]([C:9]([F:12])([F:11])[F:10])=[CH:4][N:3]=1.[C:13]([N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)(OC(C)(C)C)=O>>[CH3:2][C:7]1[C:13]([N:20]2[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]2)=[N:3][CH:4]=[C:5]([C:9]([F:12])([F:11])[F:10])[CH:6]=1

Participants

3

Reactant 2

HCID 1122342,3-Dichloro-5-(trifluoromethyl)pyridineHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 584847291-(3-Methyl-5-trifluoromethylpyridin-2-yl)piperazineYield 22.5%

Procedure

Using 2,3-dichloro-5-trifluoromethylpyridine (25 g) and 1-Boc-piperazine (23.84 g) and by the reaction and treatment in the same manner as in Preparation Example 79, the title compound (6.38 g) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 79

Sources & evidence

ORD record
ord-36066685dac14c4a8a25ffda38897d9f
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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