Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2411212Generated: October 25, 2026

2,3-Dichloro-5-(trifluoromethyl)pyridine → 1-(3-Methyl-5-trifluoromethylpyridin-2-yl)piperazine

https://huagongshe.com/reaction/2411212

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,3-Dichloro-5-(trifluoromethyl)pyridineHCID 112234—
Reactanttert-Butyl piperazine-1-carboxylateHCID 143452—
Product1-(3-Methyl-5-trifluoromethylpyridin-2-yl)piperazineHCID 5848472922.5%

Reaction Steps

Using 2,3-dichloro-5-trifluoromethylpyridine (25 g) and 1-Boc-piperazine (23.84 g) and by the reaction and treatment in the same manner as in Preparation Example 79, the title compound (6.38 g) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08816079B2
Source datasetuspto-grants-2014_08
ORD IDord-36066685dac14c4a8a25ffda38897d9f
Source noteuspto-grants-2014_08