HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-bis(2-chloroethyl)-p-toluenesulphonamide → 1-(4-Methyl-2-trifluoromethylphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-bis(2-chloroethyl)-p-toluenesulphonamide | HCID 96039 | — |
| Reactant | 4-Methyl-2-(trifluoromethyl)aniline | HCID 2737710 | — |
| Product | 1-(4-Methyl-2-trifluoromethylphenyl)piperazine | HCID 21363835 | 26.4% |
Reaction Steps
Using 4-methyl-2-trifluoromethylphenylamine (1 g) and N,N-bis(2-chloroethyl)-p-toluenesulfonamide (1.69 g) and by the reaction and treatment in the same manner as in Preparation Example 95, the title compound (368 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-7ae19ebd6fbd4d77aceb3d0a2b2ca217 |
| Source note | uspto-grants-2014_08 |