N,N-bis(2-chloroethyl)-p-toluenesulphonamide → 1-(4-Methyl-2-trifluoromethylphenyl)piperazine

HRID 2411228Notes

Reaction equation

HRID 2411228 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:3]=1.Cl[CH2:14][CH2:15][N:16]([CH2:27][CH2:28]Cl)S(C1C=CC(C)=CC=1)(=O)=O>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:28][CH2:27][NH:16][CH2:15][CH2:14]2)=[C:4]([C:9]([F:10])([F:11])[F:12])[CH:3]=1

Participants

3

Reactant 2

HCID 96039N,N-bis(2-chloroethyl)-p-toluenesulphonamideHCID 27377104-Methyl-2-(trifluoromethyl)aniline

Product 1

HCID 213638351-(4-Methyl-2-trifluoromethylphenyl)piperazineYield 26.4%

Procedure

Using 4-methyl-2-trifluoromethylphenylamine (1 g) and N,N-bis(2-chloroethyl)-p-toluenesulfonamide (1.69 g) and by the reaction and treatment in the same manner as in Preparation Example 95, the title compound (368 mg) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 95

Sources & evidence

ORD record
ord-7ae19ebd6fbd4d77aceb3d0a2b2ca217
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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