N,N-bis(2-chloroethyl)-p-toluenesulphonamide → HCID 71252079, compound

HRID 2411232Notes

Reaction equation

HRID 2411232 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[CH2:9][OH:10].Cl[CH2:12][CH2:13][N:14]([CH2:25][CH2:26]Cl)S(C1C=CC(C)=CC=1)(=O)=O>>[CH3:8][C:5]1[CH:6]=[CH:7][C:2]([N:1]2[CH2:26][CH2:25][NH:14][CH2:13][CH2:12]2)=[C:3]([CH2:9][OH:10])[CH:4]=1

Participants

3

Reactant 2

HCID 96039N,N-bis(2-chloroethyl)-p-toluenesulphonamideHCID 5764502-Amino-5-methylbenzyl alcohol

Product 1

HCID 71252079HCID 71252079, compoundYield 55.4%

Procedure

Using (2-amino-5-methylphenyl)methanol (1 g) and N,N-bis(2-chloroethyl)-p-toluenesulfonamide (2.1 g) and by the reaction and treatment in the same manner as in Preparation Example 95, the title compound (810 mg) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 95

Sources & evidence

ORD record
ord-36baa1be3e714473af945bbcaf9c756c
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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