4-Iodobenzoyl chloride → [4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

HRID 2411244Notes

Reaction equation

HRID 2411244 reaction equation
[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[I:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](Cl)=[O:21])=[CH:18][CH:17]=1>>[CH3:1][C:2]1[C:3]([N:9]2[CH2:10][CH2:11][N:12]([C:20]([C:19]3[CH:23]=[CH:24][C:16]([I:15])=[CH:17][CH:18]=3)=[O:21])[CH2:13][CH2:14]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

3

Reactant 2

HCID 743734-Iodobenzoyl chlorideHCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazine

Product 1

HCID 58484535[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanoneYield 95.6%

Procedure

Using 1-(3,5-dimethylpyridin-2-yl)piperazine (3.8 g) described in Preparation Example 79 and 4-iodobenzoyl chloride (5.3 g) and by the reaction and treatment in the same manner as in Preparation Example 108, the title compound (8 g) was obtained.

Sources & evidence

ORD record
ord-6fe34459c5264dce8e8094065ed0e649
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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