1-(2,4-Xylyl)piperazine → (4-Bromo-2-fluorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone

HRID 2411247Notes

Reaction equation

HRID 2411247 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([F:11])[CH:3]=1.[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:14]3[CH:15]=[CH:16][C:17]([CH3:19])=[CH:18][C:13]=3[CH3:12])[CH2:21][CH2:22]2)=[O:8])=[C:4]([F:11])[CH:3]=1

Participants

3

Reactant 2

HCID 705441-(2,4-Xylyl)piperazineHCID 3026814-Bromo-2-fluorobenzoic acid

Product 1

HCID 58484705(4-Bromo-2-fluorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanoneYield 100.8%

Procedure

Using 4-bromo-2-fluorobenzoic acid (5 g) and 1-(2,4-dimethylphenyl)piperazine (4.4 g) and by the reaction and treatment in the same manner as in Preparation Example 109, the title compound (9 g) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 109

Sources & evidence

ORD record
ord-5f9cb00d842e44e0962bdd0bb478d81c
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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