HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-fluorobenzoyl chloride → (4-Bromo-2-fluorophenyl)[4-(3-cyclopropyl-5-methylpyridin-2-yl)piperazin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-fluorobenzoyl chloride | HCID 2734026 | — |
| Reactant | 1-(3-Cyclopropyl-5-methylpyridin-2-yl)piperazine hydrochloride | HCID 67380775 | — |
| Product | (4-Bromo-2-fluorophenyl)[4-(3-cyclopropyl-5-methylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484686 | 54.6% |
Reaction Steps
Using 4-bromo-2-fluorobenzoyl chloride (2.6 g) and 1-(3-cyclopropyl-5-methylpyridin-2-yl)piperazine hydrochloride (2.8 g) described in Preparation Example 85 and by the reaction and treatment in the same manner as in Preparation Example 108, the title compound (2.5 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-7789bbada3d04b09b9203c0f7b0aeab7 |
| Source note | uspto-grants-2014_08 |