5-Bromopyridine-2-carboxylic acid → HCID 71252936, compound

HRID 2411269Notes

Reaction equation

HRID 2411269 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[CH2:11]([C:13]1[CH:14]=[C:15]([CH3:25])[C:16]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:17][CH:18]=1)[CH3:12]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([N:22]2[CH2:23][CH2:24][N:19]([C:16]3[C:15]([CH3:25])=[CH:14][C:13]([CH2:11][CH3:12])=[CH:18][N:17]=3)[CH2:20][CH2:21]2)=[O:10])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 6085445-Bromopyridine-2-carboxylic acidHCID 584845781-(5-Ethyl-3-methylpyridin-2-yl)piperazine

Product 1

HCID 71252936HCID 71252936, compoundYield 42.8%

Procedure

Using 5-bromo-2-picolinic acid (206 mg) and 1-(5-ethyl-3-methylpyridin-2-yl)piperazine (220 mg) described in Preparation Example 81 and by the reaction and treatment in the same manner as in Preparation Example 109, the title compound (170 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 81 and by the reaction and treatment in the same manner as in Preparation Example 109

Sources & evidence

ORD record
ord-5c8cc4b171b54998b951eed6d25fc6d4
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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