1-(5-Bromo-3-methylpyridin-2-yl)piperazine → HCID 58484740, compound

HRID 2411270Notes

Reaction equation

HRID 2411270 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[Br:12][C:13]1[CH:14]=[C:15]([CH3:25])[C:16]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:17][CH:18]=1>>[Br:12][C:13]1[CH:14]=[C:15]([CH3:25])[C:16]([N:19]2[CH2:20][CH2:21][N:22]([C:6]([C:5]3[CH:4]=[N:3][C:2]([F:1])=[CH:10][C:9]=3[CH3:11])=[O:8])[CH2:23][CH2:24]2)=[N:17][CH:18]=1

Participants

3

Reactant 2

HCID 467392701-(5-Bromo-3-methylpyridin-2-yl)piperazineHCID 467392746-Fluoro-4-methylpyridine-3-carboxylic acid

Product 1

HCID 58484740HCID 58484740, compoundYield 86.8%

Procedure

Using 6-fluoro-4-methylnicotinic acid (1.00 g) and 1-(5-bromo-3-methylpyridin-2-yl)piperazine (1.65 g) and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (2.20 g) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 111

Sources & evidence

ORD record
ord-fab4b36cb0cd42b9b664d2b8db0c9d9a
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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