Cyclopropylboronic acid → HCID 58484562, compound

HRID 2411271Notes

Reaction equation

Br[C:2]1[CH:3]=[C:4]([CH3:24])[C:5]([N:8]2[CH2:13][CH2:12][N:11]([C:14]([C:16]3[CH:17]=[N:18][C:19]([F:23])=[CH:20][C:21]=3[CH3:22])=[O:15])[CH2:10][CH2:9]2)=[N:6][CH:7]=1.[CH:25]1(B(O)O)[CH2:27][CH2:26]1>>[CH:25]1([C:2]2[CH:3]=[C:4]([CH3:24])[C:5]([N:8]3[CH2:13][CH2:12][N:11]([C:14]([C:16]4[CH:17]=[N:18][C:19]([F:23])=[CH:20][C:21]=4[CH3:22])=[O:15])[CH2:10][CH2:9]3)=[N:6][CH:7]=2)[CH2:27][CH2:26]1

Participants

Reactant 2

HCID 2760897Cyclopropylboronic acid

HCID 58484740HCID 58484740, compound

Product 1

HCID 58484562HCID 58484562, compoundYield 120.5%

Procedure

Using [4-(5-bromo-3-methylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone (2.2 g) described in Preparation Example 139 and cyclopropylboronic acid (721 mg) and by the reaction and treatment in the same manner as in Preparation Example 100, the title compound (2.39 g) was obtained.

Sources & evidence

ORD record: ord-c132e2d5606f40c3817570d7c280ad56
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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