6-Bromonicotinic acid → (6-Bromopyridin-3-yl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone

HRID 2411274Notes

Reaction equation

HRID 2411274 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.Cl.[CH:12]1([C:15]2[C:16]([N:24]3[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)=[N:17][CH:18]=[C:19]([CH:21]3[CH2:23][CH2:22]3)[CH:20]=2)[CH2:14][CH2:13]1>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:27]2[CH2:28][CH2:29][N:24]([C:16]3[C:15]([CH:12]4[CH2:13][CH2:14]4)=[CH:20][C:19]([CH:21]4[CH2:23][CH2:22]4)=[CH:18][N:17]=3)[CH2:25][CH2:26]2)=[O:8])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 2389326-Bromonicotinic acidHCID 673810941-(3,5-Dicyclopropylpyridin-2-yl)piperazine hydrochloride

Product 1

HCID 58484777(6-Bromopyridin-3-yl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanoneYield 96.9%

Procedure

Using 6-bromonicotinic acid (2 g) and 1-(3,5-dicyclopropylpyridin-2-yl)piperazine hydrochloride (3.2 g) described in Preparation Example 87 and by the reaction and treatment in the same manner as in Preparation Example 119, the title compound (4.1 g) was obtained.

Workup

  1. customdescribed in Preparation Example 87 and by the reaction and treatment in the same manner as in Preparation Example 119

Sources & evidence

ORD record
ord-d65f366f295e486581403922604ac5cb
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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