HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromonicotinic acid → (6-Bromopyridin-3-yl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromonicotinic acid | HCID 238932 | — |
| Reactant | 1-(3,5-Dicyclopropylpyridin-2-yl)piperazine hydrochloride | HCID 67381094 | — |
| Product | (6-Bromopyridin-3-yl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484777 | 96.9% |
Reaction Steps
Using 6-bromonicotinic acid (2 g) and 1-(3,5-dicyclopropylpyridin-2-yl)piperazine hydrochloride (3.2 g) described in Preparation Example 87 and by the reaction and treatment in the same manner as in Preparation Example 119, the title compound (4.1 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-d65f366f295e486581403922604ac5cb |
| Source note | uspto-grants-2014_08 |