5-Bromopyridine-2-carboxylic acid → HCID 71251982, compound

HRID 2411278Notes

Reaction equation

HRID 2411278 reaction equation
[CH3:1][C:2]1[C:3]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[N:4][C:5]([CH3:9])=[C:6]([CH3:8])[CH:7]=1.[Br:16][C:17]1[CH:18]=[CH:19][C:20]([C:23](O)=[O:24])=[N:21][CH:22]=1>>[Br:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]([N:13]2[CH2:12][CH2:11][N:10]([C:3]3[C:2]([CH3:1])=[CH:7][C:6]([CH3:8])=[C:5]([CH3:9])[N:4]=3)[CH2:15][CH2:14]2)=[O:24])=[N:21][CH:22]=1

Participants

3

Reactant 2

HCID 6085445-Bromopyridine-2-carboxylic acidHCID 584848231-(3,5,6-Trimethylpyridin-2-yl)piperazine

Product 1

HCID 71251982HCID 71251982, compoundYield 63.3%

Procedure

Using 1-(3,5,6-trimethylpyridin-2-yl)piperazine (1.5 g) described in Preparation Example 92 and 5-bromo-2-picolinic acid (1.5 g) and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (1.8 g) was obtained

Sources & evidence

ORD record
ord-a1a4d5369e314ca38a545bb53b0eec6c
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…