1-(2,4-Xylyl)piperazine → (4-Amino-2-trifluoromethylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone

HRID 2411281Notes

Reaction equation

HRID 2411281 reaction equation
[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=O)=[C:6]([C:13]([F:16])([F:15])[F:14])[CH:5]=1)([O-])=O.[CH3:17][C:18]1[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][C:19]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[NH2:1][C:4]1[CH:12]=[CH:11][C:7]([C:8]([N:28]2[CH2:29][CH2:30][N:25]([C:19]3[CH:20]=[CH:21][C:22]([CH3:24])=[CH:23][C:18]=3[CH3:17])[CH2:26][CH2:27]2)=[O:10])=[C:6]([C:13]([F:16])([F:15])[F:14])[CH:5]=1

Participants

3

Reactant 2

HCID 705441-(2,4-Xylyl)piperazineHCID 27827374-Nitro-2-(trifluoromethyl)benzoic acid

Product 1

HCID 86676758(4-Amino-2-trifluoromethylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanoneYield 106.3%

Procedure

Using 4-nitro-2-trifluoromethylbenzoic acid (500 mg) and 1-(2,4-dimethylphenyl)piperazine (403 mg) and by the reaction and treatment in the same manner as in Preparation Example 148, the title compound (850 mg) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 148

Sources & evidence

ORD record
ord-a0489e466a9349c3a9e8ff44c57850b1
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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