HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2,4-Xylyl)piperazine → (4-Amino-2-trifluoromethylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2,4-Xylyl)piperazine | HCID 70544 | — |
| Reactant | 4-Nitro-2-(trifluoromethyl)benzoic acid | HCID 2782737 | — |
| Product | (4-Amino-2-trifluoromethylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone | HCID 86676758 | 106.3% |
Reaction Steps
Using 4-nitro-2-trifluoromethylbenzoic acid (500 mg) and 1-(2,4-dimethylphenyl)piperazine (403 mg) and by the reaction and treatment in the same manner as in Preparation Example 148, the title compound (850 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-a0489e466a9349c3a9e8ff44c57850b1 |
| Source note | uspto-grants-2014_08 |