Pyrrolidine → HCID 86676761, compound

HRID 2411286Notes

Reaction equation

HRID 2411286 reaction equation
Br[C:2]1[CH:11]=[C:10]([N+:12]([O-])=O)[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=O.[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1.[CH3:20][C:21]1[CH:26]=[C:25]([CH3:27])[CH:24]=[CH:23][C:22]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[NH2:12][C:10]1[CH:9]=[CH:8][C:3]([C:4]([N:31]2[CH2:32][CH2:33][N:28]([C:22]3[CH:23]=[CH:24][C:25]([CH3:27])=[CH:26][C:21]=3[CH3:20])[CH2:29][CH2:30]2)=[O:6])=[C:2]([N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)[CH:11]=1

Participants

4

Reactant 3

HCID 31268PyrrolidineHCID 705441-(2,4-Xylyl)piperazineHCID 15833211Methyl 2-Bromo-4-nitrobenzoate

Product 1

HCID 86676761HCID 86676761, compound

Procedure

Using methyl 2-bromo-4-nitrobenzoate (1.7 g), pyrrolidine (0.54 mL) and 1-(2,4-dimethylphenyl)piperazine (999 mg) and by the reaction and treatment in the same manner as in Preparation Example 151, the title compound (268 mg) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 151

Sources & evidence

ORD record
ord-a5013e5d6d2440fc9a58d4921b4097ae
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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