2-Fluoro-4-iodobenzoic acid → [4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](2-fluoro-4-iodophenyl)methanone

HRID 2411291Notes

Reaction equation

HRID 2411291 reaction equation
[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[F:15][C:16]1[CH:24]=[C:23]([I:25])[CH:22]=[CH:21][C:17]=1[C:18](O)=[O:19]>>[CH3:1][C:2]1[C:3]([N:9]2[CH2:10][CH2:11][N:12]([C:18]([C:17]3[CH:21]=[CH:22][C:23]([I:25])=[CH:24][C:16]=3[F:15])=[O:19])[CH2:13][CH2:14]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

3

Reactant 2

HCID 27745162-Fluoro-4-iodobenzoic acidHCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazine

Product 1

HCID 71252432[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](2-fluoro-4-iodophenyl)methanoneYield 80.8%

Procedure

Using 1-(3,5-dimethylpyridin-2-yl)piperazine (1.44 g) described in Preparation Example 79 and 2-fluoro-4-iodobenzoic acid (2 g) and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (2.67 g) was obtained.

Sources & evidence

ORD record
ord-7974bc993dad43468e80dde10354f266
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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