HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-4-iodobenzoic acid → [4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](2-fluoro-4-iodophenyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-4-iodobenzoic acid | HCID 2774516 | — |
| Reactant | 1-(3,5-Dimethylpyridin-2-yl)piperazine | HCID 58484496 | — |
| Product | [4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](2-fluoro-4-iodophenyl)methanone | HCID 71252432 | 80.8% |
Reaction Steps
Using 1-(3,5-dimethylpyridin-2-yl)piperazine (1.44 g) described in Preparation Example 79 and 2-fluoro-4-iodobenzoic acid (2 g) and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (2.67 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-7974bc993dad43468e80dde10354f266 |
| Source note | uspto-grants-2014_08 |