HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → [4-(2,4-Dimethylphenyl)piperazin-1-yl](4-iodo-2-methanesulfonylphenyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | (4-Bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone | HCID 58484856 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Product | [4-(2,4-Dimethylphenyl)piperazin-1-yl](4-iodo-2-methanesulfonylphenyl)methanone | HCID 71252305 | 82% |
Reaction Steps
Using (4-bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (979 mg) described in Preparation Example 110, sodium iodide (650 mg) and copper(I) iodide (205 mg) and by the reaction and treatment in the same manner as in Preparation Example 154, the title compound (886 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-ddc5de041c0a4118a8157ad00872394b |
| Source note | uspto-grants-2014_08 |