HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → HCID 71252509, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | (4-Bromo-2,6-difluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484761 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Product | HCID 71252509 | HCID 71252509 | 81.3% |
Reaction Steps
Using (4-bromo-2,6-difluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (820 mg) described in Preparation Example 111, sodium iodide (599 mg) and copper(I) iodide (189 mg) and by the reaction and treatment in the same manner as in Preparation Example 154, the title compound (743 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-2fa5d7e6317a4ea89facb58415991f47 |
| Source note | uspto-grants-2014_08 |