Sodium Iodide → HCID 71252509, compound

HRID 2411294Notes

Reaction equation

HRID 2411294 reaction equation
Br[C:2]1[CH:7]=[C:6]([F:8])[C:5]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[CH:19][N:18]=3)[CH2:13][CH2:12]2)=[O:10])=[C:4]([F:25])[CH:3]=1.[I-:26].[Na+]>[Cu]I>[F:8][C:6]1[CH:7]=[C:2]([I:26])[CH:3]=[C:4]([F:25])[C:5]=1[C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[CH:19][N:18]=2)[CH2:13][CH2:12]1)=[O:10]

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 58484761(4-Bromo-2,6-difluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252509HCID 71252509, compoundYield 81.3%

Reagents, catalysts & solvents 1

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)Catalyst

Procedure

Using (4-bromo-2,6-difluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (820 mg) described in Preparation Example 111, sodium iodide (599 mg) and copper(I) iodide (189 mg) and by the reaction and treatment in the same manner as in Preparation Example 154, the title compound (743 mg) was obtained.

Sources & evidence

ORD record
ord-2fa5d7e6317a4ea89facb58415991f47
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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