2-Fluoro-4-iodobenzoic acid → (2-Fluoro-4-iodophenyl)[4-(3-methyl-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]methanone

HRID 2411297Notes

Reaction equation

HRID 2411297 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([I:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:12][C:13]1[C:14]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[N:15][CH:16]=[C:17]([C:19]([F:22])([F:21])[F:20])[CH:18]=1>>[F:1][C:2]1[CH:10]=[C:9]([I:11])[CH:8]=[CH:7][C:3]=1[C:4]([N:26]1[CH2:27][CH2:28][N:23]([C:14]2[C:13]([CH3:12])=[CH:18][C:17]([C:19]([F:22])([F:20])[F:21])=[CH:16][N:15]=2)[CH2:24][CH2:25]1)=[O:6]

Participants

3

Reactant 2

HCID 27745162-Fluoro-4-iodobenzoic acidHCID 584847291-(3-Methyl-5-trifluoromethylpyridin-2-yl)piperazine

Product 1

HCID 71252468(2-Fluoro-4-iodophenyl)[4-(3-methyl-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]methanoneYield 102.9%

Procedure

Using 2-fluoro-4-iodobenzoic acid (266 mg) and 1-(3-methyl-5-trifluoromethylpyridin-2-yl)piperazine (245 mg) described in Preparation Example 84 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (507 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 84 and by the reaction and treatment in the same manner as in Preparation Example 111

Sources & evidence

ORD record
ord-5680c776d9404174bb379e899b2b1c18
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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