HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-4-iodobenzoic acid → (2-Fluoro-4-iodophenyl)[4-(3-methyl-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-4-iodobenzoic acid | HCID 2774516 | — |
| Reactant | 1-(3-Methyl-5-trifluoromethylpyridin-2-yl)piperazine | HCID 58484729 | — |
| Product | (2-Fluoro-4-iodophenyl)[4-(3-methyl-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]methanone | HCID 71252468 | 102.9% |
Reaction Steps
Using 2-fluoro-4-iodobenzoic acid (266 mg) and 1-(3-methyl-5-trifluoromethylpyridin-2-yl)piperazine (245 mg) described in Preparation Example 84 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (507 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-5680c776d9404174bb379e899b2b1c18 |
| Source note | uspto-grants-2014_08 |